CADET is a fast and accurate solver for a comprehensive model family of biotechnological processes. Applications include chromatography, filtration, crystallization, and fermentation. The open source software implements state-of-the-art mathematical algorithms and scientific computing techniques.
CADET is developed at the Institute of Bio- and Geosciences 1 (IBG-1) of Forschungszentrum Jülich (FZJ). The heart of the CADET software is a fast and accurate solver for a comprehensive model family. Typical applications include but are not limited to chromatography, filtration, crystallization, and fermentation. CADET can handle arbitrary sequences and networks of unit operations, including reactors, tanks, tubes, pumps, valves, detectors, etc. The resulting models are solved at system level with state-of-the-art mathematical algorithms and scientific computing techniques. In addition to the solver, tools for parameter estimation and process optimization are provided.
We owe a special thanks to Eric von Lieres and the entire CADET team for making this valuable computational tool available to the scientific community.
The remarkable open-source and more variable toolbox named CADET was developed and successfully used for the modeling of affinity chromatography processes [...].
For their educational and patient introduction to chromatographic modelling and the training I received in using the CADET system, I would like to thank Eric von Lieres, Juliane Diedrich and William Heymann of Forschungszentrum Jülich. The discussions about mixing behaviors and the general capabilities of a system like CADET and the possibilities it provides were eye-opening.
We also thank Prof. Eric von Lieres of Forschungszentrum Jülich for making CADET available for the simulations.
The authors would like to acknowledge excellent support from Dr. Eric von Lieres and his research group at Forschungszentrum Jülich GmbH Germany with respect to CADET simulations.