calibr8
calibr8 is a Python toolbox for likelihood-based calibration modeling and Bayesian inference. It supports uni- and multivariate problems, continuous & discrete distributions and includes ready to use models for many non-linear problems. It integrates with PyMC for advanced Bayesian inference.
Description
calibr8
This package provides templates and functions for performing likelihood-based calibration modeling. To see implementation examples & excercises, you can go to notebooks/.
Installation
calibr8 is released on PyPI:
pip install calibr8
Documentation
Read the package documentation here.
Usage and Citing
calibr8 is licensed under the GNU Affero General Public License v3.0.
When using calibr8 in your work, please cite the Helleckes & Osthege et al. (2022) paper and the corresponding software version.
Note that the paper is a shared first co-authorship, which can be indicated by 1 in the bibliography.
@article{calibr8Paper,
doi = {10.1371/journal.pcbi.1009223},
author = {Helleckes$^1$, Laura Marie and
Osthege$^1$, Michael and
Wiechert, Wolfgang and
von Lieres, Eric and
Oldiges, Marco},
journal = {PLOS Computational Biology},
publisher = {Public Library of Science},
title = {Bayesian and calibration, process modeling and uncertainty quantification in biotechnology},
year = {2022},
month = {03},
volume = {18},
url = {https://doi.org/10.1371/journal.pcbi.1009223},
pages = {1-46},
number = {3}
}
@software{calibr8version,
author = {Michael Osthege and
Laura Helleckes},
title = {JuBiotech/calibr8: v6.5.2},
month = mar,
year = 2022,
publisher = {Zenodo},
version = {v6.5.2},
doi = {10.5281/zenodo.4127012},
url = {https://doi.org/10.5281/zenodo.4127012}
}
Head over to Zenodo to generate a BibTeX citation for the latest release.
- AGPL-3.0-or-later
Participating organisations
Reference papers
Mentions
- 1.Author(s): Montana N. Carlozo, Ke Wang, Alexander W. DowlingPublished in Industrial & Engineering Chemistry Research by American Chemical Society (ACS) in 2025, page: 18277-1829710.1021/acs.iecr.4c03468
- 2.Author(s): You Lu, Li Qi, QinZheng Xu, ZhuoHuan Li, Hao Duan, Fei He, Na Zhao, James M. HymanPublished in Journal of Immunological Methods by Elsevier BV in 2025, page: 11384710.1016/j.jim.2025.113847
- 3.Author(s): Laura Marie Helleckes, Kira Küsters, Christian Wagner, Rebecca Hamel, Ronja Saborowski, Jan Marienhagen, Wolfgang Wiechert, Marco OldigesPublished in Microbial Cell Factories by Springer Science and Business Media LLC in 202410.1186/s12934-024-02319-y
- 4.Author(s): Valentin Steier, Michael Osthege, Laura M. Helleckes, Maximilian Siska, Eric von Lieres, Wolfgang Wiechert, Sebastian J. Reich, Christian U. Riedel, Marco OldigesPublished in Biotechnology Progress by Wiley in 202410.1002/btpr.3495
- 5.Author(s): Florian Schunck, Bernhard Kodritsch, Martin Krauss, Wibke Busch, Andreas FocksPublished in Environmental Science & Technology by American Chemical Society (ACS) in 2024, page: 21942-2195310.1021/acs.est.4c06267
- 6.Author(s): Enrico Orsi, Lennart Schada von Borzyskowski, Stephan Noack, Pablo I. Nikel, Steffen N. LindnerPublished in Nature Communications by Springer Science and Business Media LLC in 202410.1038/s41467-024-46574-4
- 7.Author(s): Oriol Abril-Pla, Virgile Andreani, Colin Carroll, Larry Dong, Christopher J. Fonnesbeck, Maxim Kochurov, Ravin Kumar, Junpeng Lao, Christian C. Luhmann, Osvaldo A. Martin, Michael Osthege, Ricardo Vieira, Thomas Wiecki, Robert ZinkovPublished in PeerJ Computer Science by PeerJ in 2023, page: e151610.7717/peerj-cs.1516
- 8.Author(s): Heiko Steinhoff, Maurice Finger, Michael Osthege, Corinna Golze, Simone Schito, Stephan Noack, Jochen Büchs, Alexander GrünbergerPublished in Biotechnology and Bioengineering by Wiley in 2023, page: 1288-130210.1002/bit.28345
- 9.Author(s): Jaye L. Verniero, J. Juno, V. Sadykov, P. Wright, S. Schonfeld, B. Alterman, P. Mostafavi, Y. Rivera, J. Dahlin, S. A. Spitzer, N. H. Mathews, M. KirkPublished in Bulletin of the AAS by American Astronomical Society in 202310.3847/25c2cfeb.28b02668
- 10.Author(s): Chen Wang, Xu Wu, Ziyu Xie, Tomasz KozlowskiPublished in Energies by MDPI AG in 2023, page: 766410.3390/en16227664
- 11.Author(s): Laura M. Helleckes, Carolin Müller, Tim Griesbach, Vera Waffenschmidt, Matthias Moch, Michael Osthege, Wolfgang Wiechert, Marco OldigesPublished in Biotechnology and Bioengineering by Wiley in 2022, page: 139-15310.1002/bit.28261
- 12.Author(s): Nikolas von den Eichen, Michael Osthege, Michaela Dölle, Lukas Bromig, Wolfgang Wiechert, Marco Oldiges, Dirk Weuster-BotzPublished in Bioprocess and Biosystems Engineering by Springer Science and Business Media LLC in 2022, page: 1939-195410.1007/s00449-022-02797-7
- 13.Author(s): Michael Osthege, Niklas Tenhaef, Rebecca Zyla, Carolin Müller, Johannes Hemmerich, Wolfgang Wiechert, Stephan Noack, Marco OldigesPublished in Engineering in Life Sciences by Wiley in 2022, page: 242-25910.1002/elsc.202100108
- 14.Author(s): Luca Capua, Yann Sprunger, H. Elettro, F. Risch, A. Grammoustianou, R. Midahuen, T. Ernst, S. Barraud, R. Gill, A. M. IonescuPublished in IEEE Transactions on Electron Devices by Institute of Electrical and Electronics Engineers (IEEE) in 2022, page: 2159-216510.1109/ted.2022.3144108
- 1.Author(s): Florian Schunck, Wibke Busch, Andreas FocksPublished in 202510.1101/2025.05.09.652942
- 2.Author(s): Wolfgang Wiechert, Laura M Helleckes, Katharina NöhPublished in 202510.1016/j.copbio.2025.103382
- 3.Author(s): Laura Marie Helleckes, Kira Küsters, Christian Wagner, Rebecca Hamel, Ronja Saborowski, Jan Marienhagen, Wolfgang Wiechert, Marco OldigesPublished by Research Square Platform LLC in 202310.21203/rs.3.rs-3659338/v1
- 4.Author(s): Laura M. Helleckes, Carolin Müller, Tim Griesbach, Vera Waffenschmidt, Matthias Moch, Michael Osthege, Wolfgang Wiechert, Marco OldigesPublished by Wiley in 202210.22541/au.165899165.50663165/v1